Lastly, I would like to emphasize the importance of neuropathology to young generations who are studying neuropathology. Also, for hereditary case, I'd like to review disease classification by identifying causal genes, understanding of triplet repeat disease, and the significance of intranuclear inclusion.Īs for Lewy body disease, I'd like to review the history of Parkinson's disease, which began from the description of Lewy body, establishment of concept of dementia of Lewy body disease as dementia, α‐synuclein deposition, development of intracerebral lesions, and pathological changes of whole body organ.Īs for PSP, I'd like to talk about the history of PSP and corticobasal degeneration, neuropathological characteristics, development of neuropathological staining technology, establishment of roles of glial cell, and 4R tauopathy.įor ALS, I'd like to talk about the characteristics of classic ALS, ALS with dementia (ALS‐D), frontotemporal degeneration with ubiquitin positive inclusion (FTLD‐U), TDP‐43 discovery, importance of frozen brain and brain bank, a new classification of frontotemporal degeneration (FTLD). I would like to talk about 4 diseases in particular, i.e., spinocerebellar degeneration, Lewy body disease, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS), in regard to the changes within the history of disease concepts, neuropathological features, and the history of clarifying pathogenesis.Īs for spinocerebellar degeneration, I'd like to address the themes ranging from the historical descriptions of sporadic olivo‐ponto‐cerebellar atrophy, striatonigral degeneration, and Shy‐Drager syndrome to disease concept proposal of multiple system atrophy, and discovery of glial cytoplasmic inclusion and of α‐synuclein as a causal protein. After graduating from medical school in 1969, I majored in neurology and had been engaged in research and education of neuropathology thereafter. In this lecture, I would like to talk about the role of neuropathology in nearly 50 years of effort in clarifying pathogenesis of neurodegenerative disease.
Institute of Neuropathology, Fukushimura Hospital, Aichi, Japan History of clarifying pathogenesis of neurodegenerative disease and development of neuropathology
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